In 2009 (and early 2010), I got rid of 80 pounds of emotional baggage and several clothing sizes. Consequently, I got rid of a whole lot of guilt and stress.
Starting last year, Andrew and I have been making big strides in getting rid of some older debt of ours (nearly $500 per paycheck getting removed and put down on our debt before we even see $1).
This year, we are going to get rid of a bunch of just...STUFF. We already shed a bunch when we redid our room and Thing One's room last summer. Next up is the kitchen, the attic, etc.
Here is an annotated version of a list created by Emily Co (published on savvysugar.com) of 116 things to get rid of as you work to eliminate clutter. If you do just one or two a day, it won't take long to make a big difference. (Link to original list.) Comments in italics are my own not-so-humble opinions.